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endothelin-1; preproendothelin-1; PPET1; contains: endothelin-1; ET-1; big endothelin-1 (EDN1)
Function:
- EDN1 is the most potent vasoconstrictor known Struture:
- endothelin-1 is a 21 aa peptide derived from a precursor (preproendothelin-1) of 212 aa
- belongs to the endothelin/sarafotoxin family
Compartment: secreted
Expression:
- mRNA expressed in endothelial cells & in distinct neuronal types in dorsal root ganglia & spinal cord
- ET-1 synthesis is diminished by polyphenols in extracts of red wine [2]
Pathology:
- plays a role in endothelial dysfunction & early fatty-streak formation in atherosclerosis of coronary artery disease
Related
atherosclerosis
red wine
General
endothelin
Properties
COMPARTMENT: extracellular compartment
SIZE: entity length = 212 aa
entity length = 21 aa
MW = 24 kD
MOTIF: signal sequence {1-17}
cysteine residue {C53}
MODIFICATION: cysteine residue {C67}
cysteine residue {C55}
MODIFICATION: cysteine residue {C63}
cysteine residue {C63}
MODIFICATION: cysteine residue {C55}
cysteine residue {C67}
MODIFICATION: cysteine residue {C53}
proteolytic site {73-74}
Endothelin-like {109-123}
MOTIF: cysteine residue {C109}
MODIFICATION: cysteine residue {C123}
cysteine residue {C111}
MODIFICATION: cysteine residue {C119}
cysteine residue {C119}
MODIFICATION: cysteine residue {C111}
cysteine residue {C123}
MODIFICATION: cysteine residue {C109}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 131240
MORBIDMAP 131240
UniProt P05305
Pfam PF00322
Entrez Gene 1906
Kegg hsa:1906
References
- OMIM :accession 131240
- Journal Watch 22(3):21, 2002
Corder et al, Nature 414: 863, 2001
- Entrez Gene :accession 1906
- UniProt :accession P05305
- NIEHS-SNPs
http://egp.gs.washington.edu/data/edn1/
- R&D systems' cytokine source book: endothelin-1
http://www.rndsystems.com/molecule_detail.aspx?m=1364
- Wikipedia; Note: endothelin entry
http://en.wikipedia.org/wiki/endothelin