ectopic ACTH syndrome

Etiology: -> ACTH- or CRH-producing non endocrine tumors a) bronchogenic carcinoma - small cell carcinoma (50%) b) carcinoid c) pancreatic carcinoma d) bronchial adenoma Clinical manifestations: - generalized hyperpigmentation - see Cushing's syndrome Management: - treatment of underlying malignancy may result in some reversal of hyperpigmentation

Related

adrenocorticotropic hormone; corticotropin; adrenocorticotropin (ACTH) pituitary adenoma/ACTH secreting

General

paraneoplastic syndrome Cushing's syndrome; hypercortisolism; hyperadrenocorticism; pluriglandular syndrome

References

- Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17 American College of Physicians, Philadelphia 2009, 2012, 2015