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ECT2 protein (epithelial cell-transforming sequence 2 oncogene, ECT2)
Function:
1) binds to RhoA, RhoC & Rac, but does not appear to catalyze guanine nucleotide exchange
2) associates with RACGAP1 at anaphase & during cytokinesis
Structure:
- contains 2 BRCT domains
- contains 1 DH domain (DBL-homology domain)
- contains 1 PH domain
General
phosphoprotein
Properties
SIZE: MW = 100 kD
entity length = 883 aa
MOTIF: BRCA1 C-terminal (BRCT) motif
SITE: 140-229
BRCA1 C-terminal (BRCT) motif
SITE: 235-323
Thr phosphorylation site {T328}
Dbl homology domain {421-610}
PH domain {644-763}
Database Correlations
OMIM 600586
UniProt Q9H8V3
PFAM correlations
References
- UniProt :accession Q9H8V3
- Boguski MS & McCormick F
Proteins regulating Ras and its relative.
Nature 366:643 1993
PMID: 8259209