ECS complex; elonginB/C-CUL2/5-SOCS-box protein complex; ECS E3 ubiquitin-protein ligase complex

Function: - E3 ubiquitin-protein ligase complex - mediates ubiquitination of target proteins - may serve as a rigid scaffold in the complex - may contribute to catalysis through positioning of the substrate & the ubiquitin-conjugating enzyme - E3 ubiquitin-protein ligase activity is dependent on neddylation of the cullin subunit & is inhibited by association of the deneddylated cullin with TIP120A/CAND1 (putative) - functional specificity of the ECS complex depends on the substrate recognition component Structure: - subunits include CUL2, elongin BC (TCEB1 & TCEB2), RBX1 & a variable substrate-specific adapter

Related

CBC(VHL) complex elongin BC complex

Specific

ECS(ASB1) complex ECS(ASB2) complex ECS(ASB4) complex ECS(MED8) complex ECS(PPIL5) complex ECS(VHL) complex ECS(WSB1) complex

Properties

SUBUNITS: RING-box protein 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S11} Zn+2-binding site SITE: 42-42 Zn+2-binding site SITE: 45-45 RING-finger {53-98} MOTIF: Zn+2-binding site SITE: 53-53 Zn+2-binding site SITE: 56-56 Zn+2-binding site SITE: 68-68 Zn+2-binding site SITE: 75-75 Zn+2-binding site SITE: 77-77 Zn+2-binding site SITE: 80-80 Zn+2-binding site SITE: 82-82 Zn+2-binding site SITE: 83-83 Zn+2-binding site SITE: 94-94 Zn+2-binding site SITE: 97-97 EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Cullin-2 MOTIF: Tyr phosphorylation site {Y394} Thr phosphorylation site {T661} elongin BC complex

References

UniProt :accession P62877

Components

Cullin-2; CUL-2 (CUL2) elongin BC complex RING-box protein 1; Rbx1; regulator of cullins 1; RING finger protein 75; protein ZYP (RBX1 RNF75 ROC1)