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epithelial Ca+2 channel 2; transient receptor potential cation channel subfamily V member 6; TrpV6; CaT-like; CaT-L; Ca+2 transport protein 1; CaT1; ECaC2 (TRPV6, ECAC2)
Function:
- Ca+2 selective cation channel
- probably involved in Ca+2 uptake in various tissues, including Ca+2 reabsorption in intestine
- the channel is activated by low internal Ca+2 level, probably including intracellular Ca+2 store depletion
- the Ca+2 current exhibits an inward rectification
- inactivation includes both, a rapid Ca+2-dependent & a slower Ca+2-calmodulin-dependent mechanism
- the slower mechanism may be regulated by phosphorylation
- in vitro, is slowly inhibited by Mg+2 (voltage-independent)
- heteromeric assembly with TRPV5 seems to modify channel properties
- TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (putative)
- phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation
- homotetramer & probably heterotetramer with TRPV5
- interacts with TRPV5
- interacts with S100A10 & probably with the ANAX2-S100A10 heterotetramer
- interaction with S100A10 is required for the trafficking to the plasma membrane
- interacts with BSPRY (putative)
- interacts with calmodulin
Structure:
- glycosylated (putative)
- belongs to the transient receptor (TC 1.A.4) family TrpV subfamily, TRPV6 sub-subfamily contains 5 ANK repeats
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=2
Expression:
- expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum & colon, & in pancreas, placenta, prostate & salivary gland. expressed at moderate levels in liver, kidney & testis
Pathology:
- expressed in locally advanced prostate cancer, metastatic & androgen-insensitive prostatic lesions but not detected in healthy prostate tissue & benign prostatic hyperplasia
General
transient receptor potential cation channel subfamily V (TRPV)
Properties
SIZE: MW = 83 kD
entity length = 725 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-328}
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 44-74
ankyrin repeat
NAME: ankyrin repeat
SITE: 78-107
calmodulin interaction {93-103}
ankyrin repeat
NAME: ankyrin repeat
SITE: 116-145
ankyrin repeat
NAME: ankyrin repeat
SITE: 162-191
ankyrin repeat
NAME: ankyrin repeat
SITE: 239-268
transmembrane domain {329-349}
exoplasmic loop {350-387}
MOTIF: N-glycosylation site {N358}
transmembrane domain {388-408}
cytoplasmic loop {409-419}
transmembrane domain {420-440}
exoplasmic loop {441-448}
transmembrane domain {449-469}
cytoplasmic loop {470-492}
transmembrane domain {493-513}
exoplasmic loop {514-556}
transmembrane domain {557-577}
cytoplasmic domain {578-725}
MOTIF: S100A10 interaction {598-602}
calmodulin interaction {691-711}
Thr phosphorylation site {T702}
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 606680
UniProt Q9H1D0
PFAM correlations
Entrez Gene 55503
Kegg hsa:55503
References
- UniProt :accession Q9H1D0
- Wikipedia; Note: TRPV6 entry
http://en.wikipedia.org/wiki/TRPV6
- SeattleSNPs
http://pga.gs.washington.edu/data/trpv5/