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ebola virus
Hemorrhagic fever virus.
Pathology:
- see Ebola hemorrhagic fever
Genetics:
a filovirus: linear non-segmented, - strand RNA virus
80 nm in diameter, up to 14,000 nm in length
2 viral proteins
1) glycoprotein GP
a) transmembrane protein, receptor binding
b) viral access to cells
c) directly cytotoxic
d) down-regulates integrins
e) immunosuppressive?
2) secretory glycoprotein
a) inhibits neutrophil activation
b) dimer disulfide linked, 2 -S-S- inverted orientation
Clinical manifestations:
- see Ebola hemorrhagic fever
Laboratory:
- see Ebola hemorrhagic fever
* safety precautions in handling specimens
* Ebola Virus One-Step recalled due in inaccuracy
Management:
- atoltivimab/maftivimab/odesivimab-egbn (Inmazeb) for treatment of infection caused by Zaire Ebola virus
Related
Ebola hemorrhagic fever
General
filovirus
Properties
KINGDOM: virus
GENOME-TYPE: RNA
SINGLE-STRANDED
NEGATIVE-STRAND
GENOME-SIZE: 13 kB
ENVELOPE: PRESENT
CAPSID-SYMMETRY: HELICAL
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- UCLA Department of Pathology, Lecture series, Jan 7, 2002
- Centers for Disease Control and Prevention (CDC)
Guidance for U.S. Laboratories for Managing and Testing
Routine Clinical Specimens When There is a Concern About
Ebola Virus Disease.
http://www.cdc.gov/vhf/ebola/healthcare-us/laboratories/safe-specimen-management.html