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interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein (EBI3, IL27B)
Function:
1) cytokine that drives rapid clonal expansion of naive but not memory CD4+ T-cells
2) synergizes with IL-12 to trigger IFN-gamma production of naive CD4+ T-cells (subunit of IL12 ?)
3) signals through the cytokine receptor IL27RA
4) interacts with SQSTM1
Structure: heterodimer of an alpha subunit & a beta subunit
Compartment: secreted
Expression: induction by EBV
General
interleukin
Properties
SIZE: entity length = 229 aa
MW = 25 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
fibronectin type III domain or F3 module {24-124}
MOTIF: N-glycosylation site {N55}
N-glycosylation site {N105}
fibronectin type III domain or F3 module {129-221}
Database Correlations
OMIM 605816
UniProt Q14213
Pfam PF00041
Entrez Gene 10148
Kegg hsa:10148
References
- UniProt :accession Q14213
- Wikipedia; Note: interleukin-27 entry
http://en.wikipedia.org/wiki/interleukin_27
Component-of
interleukin-27 (IL-27)