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transcription factor COE1; O/E-1; OE-1; early B-cell factor (EBF1, COE1, EBF)
Function:
- transcriptional activator
- recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (putative)
- forms either a homodimer or a heterodimer with a related family member (putative)
- interacts with ZNF423 & ZNF521, leading to prevent EBF1 to bind DNA & activate target genes
Structure:
- belongs to the COE family
- contains 1 IPT/TIG domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
General
COE family transcription factor
Properties
SIZE: entity length = 591 aa
MW = 64 kD
COMPARTMENT: cell nucleus
MOTIF: DNA interaction {63-66}
Zinc finger
NAME: Zinc finger
SITE: 151-170
EFFECTOR-BOUND: Zn+2
MOTIF: arginine residue {163}
asparagine residue {172}
DNA interaction {197-204}
DNA interaction {236-239}
IPT/TIG {262-345}
threonine-rich region {462-550}
MOTIF: threonine residue (SEVERAL)
Database Correlations
OMIM 164343
UniProt Q9UH73
Pfam PF01833
Entrez Gene 1879
Kegg hsa:1879
References
UniProt :accession Q9UH73