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receptor-binding cancer antigen expressed on SiSo cells; cancer-associated surface antigen RCAS1; estrogen receptor-binding fragment-associated gene 9 protein (EBAG9, RCAS1)

Function: - may participate in suppression of cell proliferation - induces apoptotic cell death through activation of IL-1-beta converting enzyme (ICE)-like proteases Structure: - homodimer - the coiled coil domain is necessary for homodimerization Compartment: - Golgi apparatus membrane - single-pass type 3 membrane protein - may exist as a soluble form [3] which has the same biological activities Expression: - widely expressed - expressed in ovary, testis, prostate, thymus, muscle & heart - not expressed in small intestine, colon, lymph nodes, or peripherical blood lymphocytes - induced by estrogen Pathology: - may serve as a prognostic marker for cancers such as adenocarcinoma of the lung & breast cancers - present & overexpressed in many patients suffering from breast carcinomas; expression correlates with tumor grade, suggesting that it may be involved in cancer immune escape [4] - not directly a tumor-associated antigen, but it rather modulates surface expression of tumor-associated O-linked glycan Tn when it is overexpressed, suggesting that it contributes indirectly to the antigenicity of tumor cells Note: - initially reported to be a ligand for some putative receptor present on T-cells, B-cells, NK cells & various human cell lines; however, it does not bind any receptor [4

General

phosphoprotein plasma membrane protein

Properties

SIZE: entity length = 213 aa MW = 24 kD COMPARTMENT: golgi MOTIF: transmembrane domain {7-27} Ser phosphorylation site {S36} Thr phosphorylation site {T41} Tyr phosphorylation site {Y48} Ser phosphorylation site {S86} Tyr phosphorylation site {Y94} glutamate-rich region {160-163} MOTIF: glutamate residue (SEVERAL) coiled coil {163-211}

Database Correlations

OMIM 605772 UniProt O00559 Entrez Gene 9166 Kegg hsa:9166

References

  1. UniProt :accession O00559
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/EBAG9ID40393ch8q23.html
  3. Nakashima M et al Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1. Nat Med. 1999 Aug;5(8):938-42. PMID: 10426319
  4. Engelsberg A et al The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens. J Biol Chem. 2003 Jun 20;278(25):22998-3007 PMID: 12672804