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early onset hypertension with severe exacerbation in pregnancy

Pathology: - suppression of aldosterone secretion - mutant form of receptor is associated with activation by progesterone [2] Genetics: - autosomal dominant - associated with defects in NR3C2 are a cause of Clinical manifestations: - onset of severe hypertension before the age of 20 - severe exacerbation of hypertension in pregnant women

General

hypertension in adolescents & children hypertension during pregnancy

Database Correlations

OMIM 605115

References

  1. OMIM :accession 605115
  2. Geller DS et al Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 289:119, 2000 PMID: 10884226