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CD62E, E-selectin; endothelial leukocyte adhesion molecule 1; ELAM-1; leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62 antigen-like family member E (SELE, ELAM1)

Function: - cell-surface glycoprotein with a role in immunoadhesion - mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG - may have a role in capillary morphogenesis - interacts with PSGL1/SELPLG through the sialyl Lewis X epitope; PSGL1 sulfation appears not to be required for this interaction - recognizes sialylated fucosylated ligand (CD65) on leukocytes - mediates binding to leukocytes in: a) inflammatory sites b) atherosclerosis c) tumor cell adhesion in metastasis Structure: - belongs to the selectin/LECAM family - contains 1 C-type lectin domain - contains 1 EGF-like domain - contains 6 Sushi (CCP/SCR) domains Compartment: membrane Expression: - cytokine induced endothelial cells Polymorphism: - polymorphism Ser-149 -> Arg-149 is associated with a higher risk of coronary artery disease (CAD)

Related

E-selectinin blood E-selectinin serum/plasma

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen selectin

Properties

SIZE: entity length = 610 aa MW = 67 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-21} C-type lectin {22-139} MOTIF: N-glycosylation site {N25} cysteine residue {C40} MODIFICATION: cysteine residue {C138} cysteine residue {C111} MODIFICATION: cysteine residue {C130} cysteine residue {C130} MODIFICATION: cysteine residue {C111} cysteine residue {C138} MODIFICATION: cysteine residue {C40} EGF domain {140-175} MOTIF: cysteine residue {C143} MODIFICATION: cysteine residue {C154} N-glycosylation site {N145} cysteine residue {C148} MODIFICATION: cysteine residue {C163} cysteine residue {C154} MODIFICATION: cysteine residue {C143} N-glycosylation site {N160} cysteine residue {C163} MODIFICATION: cysteine residue {C148} cysteine residue {C165} MODIFICATION: cysteine residue {C174} cysteine residue {C174} MODIFICATION: cysteine residue {C165} Sushi domain {178-239} MOTIF: N-glycosylation site {N179} cysteine residue {C180} MODIFICATION: cysteine residue {C224} N-glycosylation site {N199} N-glycosylation site {N203} cysteine residue {C210} MODIFICATION: cysteine residue {C237} cysteine residue {C224} MODIFICATION: cysteine residue {C180} cysteine residue {C237} MODIFICATION: cysteine residue {C210} Sushi domain {240-301} MOTIF: cysteine residue {C242} MODIFICATION: cysteine residue {C286} N-glycosylation site {N265} cysteine residue {C272} MODIFICATION: cysteine residue {C299} cysteine residue {C286} MODIFICATION: cysteine residue {C242} cysteine residue {C299} MODIFICATION: cysteine residue {C272} Sushi domain {303-364} MOTIF: cysteine residue {C304} MODIFICATION: cysteine residue {C349} N-glycosylation site {N312} N-glycosylation site {N332} cysteine residue {C335} MODIFICATION: cysteine residue {C362} cysteine residue {C349} MODIFICATION: cysteine residue {C304} cysteine residue {C362} MODIFICATION: cysteine residue {C335} Sushi domain {366-427} MOTIF: cysteine residue {C367} MODIFICATION: cysteine residue {C412} cysteine residue {C398} MODIFICATION: cysteine residue {C425} cysteine residue {C412} MODIFICATION: cysteine residue {C367} cysteine residue {C425} MODIFICATION: cysteine residue {C398} Sushi domain {429-490} MOTIF: cysteine residue {C430} MODIFICATION: cysteine residue {C475} cysteine residue {C461} MODIFICATION: cysteine residue {C488} cysteine residue {C475} MODIFICATION: cysteine residue {C430} cysteine residue {C488} MODIFICATION: cysteine residue {C461} Sushi domain {491-549} MOTIF: cysteine residue {C493} MODIFICATION: cysteine residue {C534} N-glycosylation site {N503} cysteine residue {C520} MODIFICATION: cysteine residue {C547} N-glycosylation site {N527} cysteine residue {C534} MODIFICATION: cysteine residue {C493} cysteine residue {C547} MODIFICATION: cysteine residue {C520} transmembrane domain {557-578}

Database Correlations

OMIM 131210 UniProt P16581 PFAM correlations Kegg hsa:6401

References

  1. UniProt :accession P16581
  2. SeattleSNPs http://pga.gs.washington.edu/data/sele/
  3. Functional glycomics gateway - glycan binding: E-selectin http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_233
  4. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002