DCX DET1-COP1 ubiquitin ligase complex

Function: - required for ubiquitination & subsequent degradation of target proteins - JUN ubiquitination & degradation Structure: - consists of: RBX1, DET1, DDB1, CUL4A & COP1

Properties

SUBUNITS: RING-box protein 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S11} Zn+2-binding site SITE: 42-42 Zn+2-binding site SITE: 45-45 RING-finger {53-98} MOTIF: Zn+2-binding site SITE: 53-53 Zn+2-binding site SITE: 56-56 Zn+2-binding site SITE: 68-68 Zn+2-binding site SITE: 75-75 Zn+2-binding site SITE: 77-77 Zn+2-binding site SITE: 80-80 Zn+2-binding site SITE: 82-82 Zn+2-binding site SITE: 83-83 Zn+2-binding site SITE: 94-94 Zn+2-binding site SITE: 97-97 EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif DET1 homolog COMPARTMENT: cell nucleus DNA damage-binding protein 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: CDT1 interaction {1-768} MOTIF: Thr phosphorylation site {T8} CUL4A interaction {391-709} Ser phosphorylation site {S757} Ser phosphorylation site {S766} CDT1/CUL4A interaction {771-1140} Cullin-4A MOTIF: Ser phosphorylation site {S10} Thr phosphorylation site {T22} Ser phosphorylation site {S99} Tyr phosphorylation site {Y227} caspase-1 inhibitor COP MOTIF: CARD domain {1-91} INHIBITS: protease

References

UniProt :accession Q7L5Y6

Components

caspase-1 inhibitor COP; CARD only domain-containing protein 1; pseudo interleukin-1 beta converting enzyme; pseudo-ICE (COP1, COP, CARD16) Cullin-4A; CUL-4A (CUL4A) DET1 homolog (De-etiolated-1 homolog, DET1) DNA damage-binding protein 1; damage-specific DNA-binding protein 1; UV-damaged DNA-binding factor; DDB p127 subunit; DNA damage-binding protein a; DDBa; UV-damaged DNA-binding protein 1; UV-DDB 1; Xeroderma pigmentosum group E-complementing protein; XPCe; XPE-binding factor; XPE-BF; HBV X-associated protein 1; XAP-1 (DDB1, XAP1) RING-box protein 1; Rbx1; regulator of cullins 1; RING finger protein 75; protein ZYP (RBX1 RNF75 ROC1)