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transcription factor E2F6 (E2F-6, E2F6)
Function:
- inhibitor of E2F-dependent transcription
- binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'
- preference for the 5'-TTTCCCGC-3' E2F recognition site
- E2F6 lacks the transcriptional activation & pocket protein binding domains
- appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression
- may silence expression via recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity
- overexpression delays exit of cells from S-phase
- component of the DRTF1/E2F transcription factor complex
- forms heterodimers with DP family members
- part of the E2F6.com-1
- complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 & YAF2
Structure: belongs to the E2F/DP family
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in all tissues examined
- highest expression in placenta, skeletal muscle, heart, ovary, kidney, small intestine & spleen
General
E2F
Properties
SIZE: entity length = 281 aa
MW = 32 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 50-129
MOTIF: Ser phosphorylation site {S67}
DEF box {95-129}
Dimerization {130-222}
MOTIF: leucine zipper
SITE: 143-164
FOR-BINDING-VIA: leucine zipper
silencer element
SITE: 173-281
MOTIF: glutamate-rich region {265-268}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 602944
UniProt O75461
Pfam PF02319
Entrez Gene 1876
Kegg hsa:1876
References
- UniProt :accession O75461
- Entrez Gene :accession 1876
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/E2F6ID521.html
Component-of
E2F6.com-1 complex