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transcription factor E2F5 (E2F-5, E2F5)
Function:
- transcriptional activator
- binds to E2F sites present in the promoter of many genes whose products are involved in cell proliferation
- may mediate growth factor-initiated signal transduction
- role in the early responses of resting cells to growth factor stimulation
- component of the DRTF1/E2F transcription factor complex
- binds cooperatively with DP-1 to E2F sites
- interaction with retinoblastoma protein RB1 or proteins RBL1 & RBL2 inhibits the E2F transactivation domain
- component of the DREAM complex in quiescent cells
Structure: belongs to the E2F/DP family
Compartment: nucleus
General
E2F
Properties
SIZE: entity length = 346 aa
MW = 38 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 33-39
MOTIF: proline residue (SEVERAL)
DNA-binding motif
SITE: 47-118
MOTIF: leucine zipper
SITE: 76-98
FOR-BINDING-VIA: leucine zipper
DEF box {81-118}
Dimerization {119-215}
serine-rich region {233-236}
MOTIF: serine residue (SEVERAL)
Transactivation {287-346}
MOTIF: RBL2 association {323-340}
Database Correlations
OMIM 600967
UniProt Q15329
Pfam PF02319
Entrez Gene 1875
Kegg hsa:1875
References
- UniProt :accession Q15329
- Entrez Gene :accession 1875
Component-of
DREAM complex (LINC complex)