heterogeneous nuclear ribonucleoprotein U-like protein 1; adenovirus early region 1B-associated protein 5; E1B-55 kDa-associated protein 5; E1B-AP5 (HNRNPUL1, E1BAP5)

Function: 1) general transcriptional regulator 2) represses general transcription driven by several virus & cellular promoters 3) activates transcription of glucocorticoid-responsive promoter in the absence of ligand stimulation in association with BRD7 4) mRNA processing & transport 5) binds avidly to poly(G) & poly(C) RNA homopolymers in vitro 6) interacts with the adenovirus type 5 (Ad5) E1B-55 kD, BRD7, HRMT1L1, TP53 & TAP 7) associates with histones & BRD7 Structure: 1) methylated a) RGG-box domain is methylated. b) methylation enhanced in late phase of adenoviral infection 2) contains 1 SPRY domain 3) contains 1 SAP domain Compartment: nucleus Alternative splicing: named isoforms=5

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein

Properties

SIZE: MW = 96 kD entity length = 856 aa COMPARTMENT: cell nucleus MOTIF: binding site SITE: 1-103 FOR-BINDING-OF: protein arginine N-methyltransferase 2 MOTIF: SAP {3-37} B30.2/SPRY {191-388} transcriptional activation domain SITE: 456-594 Ser phosphorylation site {S512} silencer element SITE: 612-658 MOTIF: consensus repeat {612-614} SEQUENCE-IS: RGG glycine-rich region {613-666} consensus repeat {620-622} SEQUENCE-IS: RGG consensus repeat {639-641} SEQUENCE-IS: RGG consensus repeat {645-647} SEQUENCE-IS: RGG consensus repeat {656-658} SEQUENCE-IS: RGG proline-rich region SITE: 692-811 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S718} glutamine-rich region {806-832} MOTIF: glutamine residue (SEVERAL)

Database Correlations

OMIM 605800 UniProt Q9BUJ2 PFAM correlations

References

UniProt :accession Q9BUJ2