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adenovirus oncoprotein E1b

The adenovirus E1b gene encodes 2 distinct transforming proteins, 19 & 55 kD proteins, both of which independently cooperate with E1a suppressing apoptosis & thereby permitting transformation by E1a [4]. E1b inhibits apoptosis via binding to & inhibiting transcriptional activity of p53 [3].

Interactions

molecular events

Specific

19 KD adenovirus oncoprotein E1b 55 KD adenovirus oncoprotein E1b

General

oncoprotein

Figures/Diagrams

Viral Inhibitors of Apoptosis

Properties

SIZE: MW = 19 kD MW = 55 kD MOTIF: binding site FOR-BINDING-OF: cellular tumor antigen p53

References

  1. Wilcock D, Lane DP. Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells. Nature. 1991 Jan 31;349(6308):429-31. PMID: 1671528
  2. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995 Mar 10;267(5203):1456-62. Review. PMID: 7878464 (apoptosis inhibitor)
  3. Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: 7677168
  4. Debbas M, White E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 1993 Apr;7(4):546-54. PMID: 8384580

Component-of

molecular complex