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adenovirus oncoprotein E1a
Pathology:
- interferes with cAMP-dependent activity of CREB
- binding to:
a) transcriptional activator proteins
b) transcriptional adaptor proteins:
- EP300
- adenovirus E1a alone initiates transformed foci in cell cultures, but fails to sustain these foci which undergo apoptosis
- E1b when coexpressed with E1a, efficiently induces transformation [2]
- over-expression of bcl-2 can also cooperate with E1a in inducing transformation [2]
- interacts with CTBP1, CTBP2 (via C-terminus)
- disrupts the interaction of CTBP1 with RBBP8
- cellular targets of the adenovirus oncoprotein E1A include:
a) E4F1
b) EP300
Interactions
molecular events
Related
adenovirus
General
oncoprotein
PEST protein
Figures/Diagrams
Damage-Related Inducers of Apoptosis
Properties
MOTIF: PEST region
binding site
FOR-BINDING-OF: transcriptional adaptor protein
binding site
FOR-BINDING-OF: retinoblastoma-associated protein
MISC-INFO: 1/2LIFE 0.5 HOURS
References
- Arany Z, Newsome D, Oldread E, Livingston DM, Eckner R.
A family of transcriptional adaptor proteins targeted by the
E1A oncoprotein.
Nature. 1995 Mar 2;374(6517):81-4.
PMID: 7870178 1995
- Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S,
White E.
The adenovirus E1A proteins induce apoptosis, which is
inhibited by the E1B 19-kDa and Bcl-2 proteins.
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7742-6.
Erratum in: Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9974.
PMID: 1457005
- UniProt :accession Q13363
Component-of
molecular complex