Search
dysbiosis
Pathology:
- disruption of intestinal bacteria-host bidirectional communication [1]
- intestinal dysbiosis is a common feature of mild cognitive impairment (MCI) & Alzheimer's disease (AD)
- Pseudomonadota (Proteobacteria) & Actinomycetota (Actinobacteria) are increased in MCI & AD
- Faecalibacterium & Roseburia are consistently reduced in MCI & AD in a small number of studies. [2]
General
pathologic process
References
- Lopez-Otin C, Blasco MA, Partridge L et al
Hallmarks of Aging: An expanding universe.
Cell. 2022 Dec 26:S0092-8674(22)01377-0
PMID: 36599349 Review.
https://www.cell.com/action/showPdf?pii=S0092-8674%2822%2901377-0
- Warren A, Wynia Z, Corr PG et al
The microbiota-gut-brain axis in mild cognitive impairment and Alzheimer's
disease: a scoping review of human studies.
Alzheimers Dement. 2026 Jan;22(1):e71023.
PMID: 41568738 PMCID: PMC12825029 Free PMC article.