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dynein

Function: - cytoplasmic dynein directs minus-end or retrograde transport of vesicles along microtubules, whereas kinesin directs plus-end or anterograde movement - dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP - ciliary dynein is the force generating protein of respiratory cilia - ciliary dynein is required for structural & functional integrity of cilia of ependymal cells lining the brain ventricles - leading dynein proteins along microtubules shorten their when the load becomes heavy, allowing trailing dyneins to catch up, with the individual proteins bunching together to better share the strain [5] - aainst even higher loads, dyneins activate catch bonds, attaching themselves to microtubules to ensure they don't get ripped off the track [5] Structure: - molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides & a number of intermediate chains & light chains - [4] depicts 2 light chains

Interactions

molecular events

Specific

cytoplasmic dynein complex 2

General

adenosine triphosphatase (ATPase) microtubule-associated protein (MAP) multisubunit protein

Properties

SIZE: MW = 1500 kD COMPARTMENT: cytoplasm MOTIF: active site (3) MOTIF: ATP-binding site NAME: ATP-binding site SUBUNITS: dynein heavy chain (2) MOTIF: active site MOTIF: adenine nucleotide-binding site dynein light chain (2) dynein intermediate chain

Database Correlations

OMIM 600112

References

  1. Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 942
  2. Kumar J, Yu H, Sheetz MP. Kinectin, an essential anchor for kinesin-driven vesicle motility. Science. 1995 Mar 24;267(5205):1834-7. PMID: 7892610
  3. OMIM :accession 600112
  4. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: 11165519
  5. Rai AK et al Molecular adaptations allow dynein to generate large collective forces inside cells. Cell, 152:172-82, 2013 PMID: 23332753

Component-of

axoneme

Components

dynein heavy chain dynein intermediate chain dynein light chain