dynactin

Function: - a large macromolecular complex required for the cytoplasmic dynein-driven movement of organelles along microtubules - the dynein-dynactin interaction is probably functions in axonal transport of vesicles & organelles Structure: - dynactin is composed of 10 distinct polypeptides of 150, 135, 62, 50, 45, 42, 37, 32, 27, & 24 kD, with a combined mass of 10 million daltons Compartment: - membrane, centrosome, kinetochore, mitotic spindle - localizes to punctate cytoplasmic structures & to the centrosome during interphase, & to kinetochores & to spindle poles throughout mitosis - colocalizes with dynein to the cleavage furrow & to midbody of dividing cells

Properties

SIZE: MW = 10000 kD

Database Correlations

OMIM 601143 MORBIDMAP 601143

References

OMIM :accession 601143

Components

dynactin (subunit 2 dynactin 50 KD subunit, dynamitin, dynactin p50, 50 kD dynein-associated polypeptide, DCTN-50, DCTN2, DCTN50) dynactin-1 (dynactin p150, p150-glued, 150 kD dynein-associated polypeptide, DP-150, DAP-150, p135, DCTN1)