Search
segment polarity protein dishevelled homolog DVL-1; dishevelled-1; DSH homolog 1 (DVL1)
Function:
- may play a role in the signal transduction pathway mediated by multiple Wnt genes
- ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome
- interaction with INVS is required for ubiquitination
- interacts with CXXC4
- interacts (via PDZ domain) with NXN (putative)
- interacts with BRD7 & INVS. interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 & CCDC88C/DAPLE
- interacts with ARRB1; the interaction is enhanced by
- phosphorylation of DVL1
Structure:
- belongs to the DSH family
- contains 1 DEP domain
- contains 1 DIX domain
- contains 1 PDZ domain (DHR domain)
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=2
General
dishevelled family protein
phosphoprotein
Properties
SIZE: entity length = 695 aa
MW = 75 kD
COMPARTMENT: cytoplasm
MOTIF: DIX {1-85}
arginine-rich region {221-224}
MOTIF: arginine residue (SEVERAL)
PDZ domain
NAME: PDZ domain
SITE: 251-323
DEP domain {425-499}
Ser phosphorylation site {S559}
Database Correlations
OMIM 601365
UniProt O14640
PFAM correlations
Entrez Gene 1855
Kegg hsa:1855
References
- UniProt :accession O14640
- Entrez Gene :accession 1855