Contents

Search

deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; dUTP nucleotidase; dUTPase; dUTP pyrophosphatase (DUT)

Function: - role in nucleotide metabolism - produces dUMP, the immediate precursor of thymidine nucleotides - decreases intracellular concentration of dUTP so that uracil cannot be incorporated into DNA - phosphorylation is necessary for activity - pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2 - phosphorylation in mature T-cells is cell cycle-dependent dUTP + H2O dUMP + diphosphate Cofactor: Mg+2 Structure: belongs to the dUTPase family Compartment: - isoform 1: mitochondrion - isoform 2: nucleus Alternative splicing: named isoforms=3 Expression: found in a variety of tissues

General

nucleotidase phosphoprotein pyrophosphatase (diphosphohydrolase)

Properties

SIZE: entity length = 252 aa MW = 27 kD COMPARTMENT: mitochondria cell nucleus MOTIF: Ser phosphorylation site {S99}

Database Correlations

OMIM 601266 UniProt P33316 Pfam PF00692 Entrez Gene 1854 ENZYME 3.6.1.23

References

  1. UniProt :accession P33316
  2. NIEHS SNPs http://egp.gs.washington.edu/data/dut/