dual specificity protein phosphatase 3 selections

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dual specificity protein phosphatase 3 (vaccinia virus phosphatase VH1-related, VHR, DUSP3)

Function: - dual specificity tyrosine/serine-threonine phosphatase highly specific for MAP kinases protein tyrosine phosphate + H₂O protein tyrosine + phosphate phosphoprotein + H₂O = a protein + phosphate Structure: - belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily - homology to CL100 phosphatase - contains 1 tyrosine-protein phosphatase domain

Interactions

molecular events

HVH1 primary response gene

General

dual specificity phosphatase

Properties

SIZE: entity length = 185 aa MW = 20 kD STATE: active state MOTIF: Tyrosine-protein phosphatase {99-169} MOTIF: cysteine residue {C124}

Database Correlations

OMIM 600183 UniProt P51452 Pfam PF00782 Entrez Gene 1845 Kegg hsa:1845 ENZYME correlations

References

Nebreda AR. Inactivation of MAP kinases. Trends Biochem Sci. 1994 Jan;19(1):1-2. Review. PMID: 8140614
UniProt :accession P51452

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