dual specificity protein phosphatase 26 (low-molecular-mass dual-specificity phosphatase 4, LDP-4, DSP-4, mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, novel amplified gene in thyroid anaplastic cancer, dual specificity phosphatase SKRP3, DUSP26, DUSP24, LDP4, MKP8, NATA1, SKRP3)

Function: - inactivates MAPK1 & MAPK3 which leads to dephosphorylation of heat shock factor protein 4 & diminishes its DNA-binding activity - inhibits MAP kinase p38 by dephosphorylating it - induces activation of MAP kinase p38 & c-Jun N-terminal kinase (JNK) - interacts with HSF4 Structure: - belongs to the protein-tyrosine phosphatase family, non-receptor class dual specificity subfamily - contains 1 tyrosine-protein phosphatase domain Compartment: cytoplasm, nucleus, Golgi Alternative splicing: named isoforms=2 Expression: - brain - in the brain, expressed ubiquitously except in hippocampus Pathology: - expressed in embryonal cancers (retinoblastoma, neuroepithelioma & neuroblastoma) & in anaplatic thyroid cancer - inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells

Properties

SIZE: MW = 24 kD entity length = 211 aa COMPARTMENT: cytoplasm cell nucleus golgi STATE: active state MOTIF: Tyrosine-protein phosphatase {61-206} MOTIF: cysteine residue {C152}

Database Correlations

UniProt Q9BV47 Pfam PF00782 ENZYME correlations

References

UniProt :accession Q9BV47