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Duke criteria for diagnosis of infectious endocarditis
Diagnostic criteria:
Major criteria:
1) echocardiographic findings, i.e. mass or valvular dehiscence
2) blood cultures positive (x 2), bacteremia with typical micro-organisms
- a single positive blood culture for Coxiella burnetti
- antibody titer > 1:800 [1]
3) new regurgitant murmur (valvular regurgitation)
Minor criteria:
1) predisposing cardiac conditions
2) history of injection drug use
3) fever of > 38 degrees C
4) vascular phenomena, i.e. signs of embolization
5) various immunological phenomena
a) glomerulonephritis
b) positive rheumatoid factor
6) miscellaneous echocardiographic & culture results
Diagnosis is made by:
1) 2 major criteria
2) 1 major & 3 minor criteria
3) 5 minor criteria
4) pathologic criteria
- culture from or histologic examination of a valvular vegetation, a vegetation that has embolized, or an intracardiac abscess
General
criteria
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 16,
17, 18. American College of Physicians, Philadelphia 1998, 2006,
2012, 2015. 2018.
- Li JS, Sexton DJ, Mick N, Nettles R et al
Proposed modifications to the Duke criteria for the diagnosis
of infective endocarditis.
Clin Infect Dis. 2000 Apr;30(4):633-8. Epub 2000 Apr 3.
PMID: 10770721