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desmoglein-4
Function:
1) component of intercellular desmosome junctions
2) interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion
3) transition from proliferation to differentiation in hair follicle keratinocytes
Compartment: membrane
Expression:
- expressed in skin, testis, prostate > salivary gland, scalp follicles (inner rooth sheath, matrix, precortex)
Pathology:
1) defects in DSG4 are the cause localized autosomal hypotrichosis
2) DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris
Related
localized autosomal hypotrichosis
pemphigus vulgaris
General
desmoglein (desmosomal glycoprotein)
Properties
COMPARTMENT: desmosome
MOTIF: glycosylation site
focal adhesion site
transmembrane domain
Ca+2-binding site
SITE: C-TERMINAL
Database Correlations
OMIM correlations
UniProt Q86SJ6
Pfam PF00028
Entrez Gene 147409
References
- OMIM :accession 607892
- Entrez Gene :accession 147409