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desmoglein-3; 130 kD pemphigus vulgaris antigen; PVA (DSG3, CDHF6)
Function:
- component of intercellular desmosome junctions
- involved in the interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion
Structure:
- Ca+2 may be bound by the cadherin-like repeats
- contains 4 cadherin domains
Compartment:
- cell membrane; single-pass type 1 membrane protein (putative)
- cell junction, desmosome
Expression:
- epidermis, tongue, tonsil, esophagus including carcinomas
Pathology:
- autoantibodies against desmoglein 3 (DSG3) are found in pemphigus vulgaris
Related
pemphigus vulgaris
General
desmoglein (desmosomal glycoprotein)
Properties
SIZE: entity length = 999 aa
MW = 108 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
cadherin domain {50-158}
MOTIF: N-glycosylation site {N110}
cadherin domain {159-268}
MOTIF: N-glycosylation site {N180}
cadherin domain {269-383}
cadherin domain {386-499}
MOTIF: N-glycosylation site {N459}
N-glycosylation site {N545}
transmembrane domain {616-640}
Desmoglein {910-935}
Desmoglein {936-966}
Database Correlations
OMIM 169615
UniProt P32926
Pfam PF00028
Entrez Gene 1830
Kegg hsa:1830
References
- UniProt :accession P32926
- Entrez Gene :accession 1830