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drug interaction

Complications: - alert fatigue associated with excessive alerts of low clinical relevance [9] Notes: - Medscape provides drug interaction checker [10]

Specific

drug interaction(s) anticonvulsants with anti-bacterial agents drug interaction(s) anticonvulsants with statins drug interaction(s) of ACE inhibitor with trimethoprim drug interaction(s) of ACE inhibitors with aliskiren drug interaction(s) of ACE inhibitors with angiotensin II receptor antagonists drug interaction(s) of ACE inhibitors with potassium-sparing diuretics drug interaction(s) of acetaminophen in combination with GLP1-agonist drug interaction(s) of acetaminophen in combination with phenylephrine drug interaction(s) of alcohol (ethanol) with varenicline drug interaction(s) of alcoholic beverage with acetaminophen drug interaction(s) of alcoholic beverage with benzodiazepines drug interaction(s) of alcoholic beverage with opiates drug interaction(s) of aldosterone antagonists with SGLT2-inhibitor drug interaction(s) of angiotensin II receptor antagonists with aliskiren drug interaction(s) of anti-platelet agents with SSRIs drug interaction(s) of antiarrhythmic agents in combination with diuretics drug interaction(s) of antibiotics with warfarin drug interaction(s) of antidepressant in combination with GLP1-agonist drug interaction(s) of antidepressant with opiates drug interaction(s) of antidepressants with benzodiazepines drug interaction(s) of antiplatelet agents with proton pump inhibitors drug interaction(s) of antipsychotics & dopamine receptor agonists drug interaction(s) of antipsycotics with benzodiazepines drug interaction(s) of antiretroviral protease inhibitor in combination with ritonavir drug interaction(s) of apixaban with NSAIDs drug interaction(s) of ARB with trimethoprim drug interaction(s) of aspirin with NSAIDs drug interaction(s) of aspirin with proton pump inhibitors drug interaction(s) of aspirin, clopidogrel & warfarin drug interaction(s) of aspirin, P2Y12 inhibitors & anticoagulants drug interaction(s) of atorvastatin with anthracycline drug interaction(s) of benzodiazepine with opiates drug interaction(s) of benzodiazepines with antidepressants drug interaction(s) of benzodiazepines with thiazide diuretics drug interaction(s) of beta blockers with ACE inhibitors drug interaction(s) of beta-2 adrenergic receptor agonists with beta adrenergic receptor antagonists drug interaction(s) of beta-2 adrenergic receptor agonists with loop diuretics drug interaction(s) of beta-2 adrenergic receptor agonists with thiazide diuretics drug interaction(s) of beta-adrenergic receptor antagonists (except atenolol) with benzodiazepines drug interaction(s) of beta-adrenergic receptor antagonists with aluminum carbonate drug interaction(s) of beta-adrenergic receptor antagonists with aluminum hydroxide drug interaction(s) of beta-adrenergic receptor antagonists with ampicillin drug interaction(s) of beta-adrenergic receptor antagonists with barbiturates drug interaction(s) of beta-adrenergic receptor antagonists with benzodiazepines drug interaction(s) of beta-adrenergic receptor antagonists with calcium channel blockers drug interaction(s) of beta-adrenergic receptor antagonists with calcium salts drug interaction(s) of beta-adrenergic receptor antagonists with cholestyramine drug interaction(s) of beta-adrenergic receptor antagonists with clonidine drug interaction(s) of beta-adrenergic receptor antagonists with colestipol drug interaction(s) of beta-adrenergic receptor antagonists with ergot alkaloids drug interaction(s) of beta-adrenergic receptor antagonists with flecainide drug interaction(s) of beta-adrenergic receptor antagonists with haloperidol drug interaction(s) of beta-adrenergic receptor antagonists with histamine H2 receptor antagonists drug interaction(s) of beta-adrenergic receptor antagonists with hydralazine drug interaction(s) of beta-adrenergic receptor antagonists with lidocaine drug interaction(s) of beta-adrenergic receptor antagonists with loop diuretics drug interaction(s) of beta-adrenergic receptor antagonists with MAO inhibitors drug interaction(s) of beta-adrenergic receptor antagonists with oral contraceptives drug interaction(s) of beta-adrenergic receptor antagonists with phenothiazines drug interaction(s) of beta-adrenergic receptor antagonists with prazosin drug interaction(s) of beta-adrenergic receptor antagonists with propafenone drug interaction(s) of beta-adrenergic receptor antagonists with quinidine drug interaction(s) of beta-adrenergic receptor antagonists with quinolones drug interaction(s) of beta-adrenergic receptor antagonists with rifampin drug interaction(s) of beta-adrenergic receptor antagonists with salicylate drug interaction(s) of beta-adrenergic receptor antagonists with sulfinpyrazone drug interaction(s) of beta-adrenergic receptor antagonists with sulfonylureas drug interaction(s) of beta-adrenergic receptor antagonists with thyroid hormone drug interaction(s) of biologic immunosuppressive agents drug interaction(s) of bisphosphonate with Ca+2 drug interaction(s) of bisphosphonates with proton pump inhibitors drug interaction(s) of boceprevir in combination with ritonavir & atazanavir drug interaction(s) of boceprevir in combination with ritonavir & darunavir drug interaction(s) of boceprevir in combination with ritonavir & Kaletra drug interaction(s) of calcineurin inhibitors with ACE inhibitors drug interaction(s) of calcineurin inhibitors with ARBs drug interaction(s) of calcium channel blockers with ACE inhibitors drug interaction(s) of calcium channel blockers with ARBs drug interaction(s) of calcium channel blockers with clarithromycin drug interaction(s) of calcium channel blockers with diuretics drug interaction(s) of calcium channel blockers with erythromycin drug interaction(s) of cholinesterase inhibitors with NSAIDs drug interaction(s) of citalopram with pimozide drug interaction(s) of clopidogrel with proton pump inhibitors drug interaction(s) of coxib with SSRI drug interaction(s) of dextromethorphan with SSRIs drug interaction(s) of digoxin in combination with macrolides drug interaction(s) of diltiazem with apixaban drug interaction(s) of diltiazem with rivaroxaban drug interaction(s) of diuretics in combination with Zn+2 drug interaction(s) of diuretics with ACE inhibitors drug interaction(s) of diuretics with angiotensin II receptor antagonists drug interaction(s) of eplerenone with clarithromycin drug interaction(s) of eplerenone with intraconazole drug interaction(s) of eplerenone with ketoconazole drug interaction(s) of eplerenone with nelfinavir drug interaction(s) of eplerenone with ritonavir drug interaction(s) of ethanol with acetaminophen drug interaction(s) of fluoroquinolones with hypoglycemic agents drug interaction(s) of fluroquinolones with amiodarone drug interaction(s) of fluroquinolones with sulfonylureas drug interaction(s) of fluticasone with HIV1 protease inhibitors drug interaction(s) of gabapentin with opiates drug interaction(s) of gemfibrozil with pioglitazone drug interaction(s) of gemfibrozil with repaglinide drug interaction(s) of gemfibrozil with rosiglitazone drug interaction(s) of ginko biloba with proton pump inhibitors drug interaction(s) of gliptins with sulfonylureas drug interaction(s) of glucocorticoids with warfarin drug interaction(s) of haloperidol with rivastigmine drug interaction(s) of hypericum perforatum (Sr John's wort) with SSRI drug interaction(s) of iron supplements in combination with antacids drug interaction(s) of levothyroxine with proton pump inhibitors drug interaction(s) of linezolid with serotonin agonists drug interaction(s) of linezolid with SNRIs drug interaction(s) of linezolid with SSRIs drug interaction(s) of lithium carbonate with ACE inhibitors drug interaction(s) of lithium carbonate with carbamazepine drug interaction(s) of lithium carbonate with CNS depressants drug interaction(s) of lithium carbonate with fluoxetine drug interaction(s) of lithium carbonate with haloperidol drug interaction(s) of lithium carbonate with iodide salts drug interaction(s) of lithium carbonate with loopt diuretics drug interaction(s) of lithium carbonate with neuromuscular blockers drug interaction(s) of lithium carbonate with NSAIDs drug interaction(s) of lithium carbonate with phenothiazine drug interaction(s) of lithium carbonate with thiazide diuretics drug interaction(s) of lithium carbonate with xanthine drug interaction(s) of loop diuretics with alpha-1 adrenergic receptor antagonist drug interaction(s) of macrolides with sulfonylureas drug interaction(s) of MAO inhibitor with caffeine drug interaction(s) of mercaptopurine in combination with allopurinol drug interaction(s) of methadone in combination with benzodiazepines drug interaction(s) of methotrexate with biological response modifier drug interaction(s) of methotrexate with caffeine drug interaction(s) of methotrexate with influenza virus vaccine drug interaction(s) of methotrexate with proton pump inhibitors drug interaction(s) of methylene blue with serotonin agonists drug interaction(s) of methylene blue with SNRIs drug interaction(s) of methylene blue with SSRIs drug interaction(s) of morphine with ethanol drug interaction(s) of nitrates with phosphodiesterase-5-inhibitors drug interaction(s) of NSAIDs & antihypertensives drug interaction(s) of NSAIDs & aspirin drug interaction(s) of NSAIDs & loop diuretics drug interaction(s) of NSAIDs with ACE inhibitors drug interaction(s) of NSAIDs with aldosterone antagonis drug interaction(s) of NSAIDs with antidepressants drug interaction(s) of NSAIDs with ARBs drug interaction(s) of NSAIDs with beta blockers drug interaction(s) of NSAIDs with glucocorticoid drug interaction(s) of NSAIDs with oral contraceptive drug interaction(s) of NSAIDs with SSRIs drug interaction(s) of NSAIDs, diuretics & ACE inhibitors drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists drug interaction(s) of ondanstetron with SSRIs drug interaction(s) of oral anticoagulants with selective serotonin reuptake inhibitor (SSRI) drug interaction(s) of oral contaceptives with Hypericum perforatum drug interaction(s) of palbociclib with proton pump inhibitors drug interaction(s) of parasympatholytic with parasympathomimetic drug interaction(s) of phosphodiesterase-5-inhibitor with nitrates drug interaction(s) of phosphodiesterase-5-inhibitor with testosterone drug interaction(s) of phosphodiesterase-5-inhibitors with alpha-1-adrenergic receptor antagonists drug interaction(s) of potassium chloride with ACE inhibitors drug interaction(s) of pregabalin with opiates drug interaction(s) of propranolol with warfarin drug interaction(s) of raloxifene with levothyroxine drug interaction(s) of raltegravir with etravirine drug interaction(s) of renin-angiotensin-aldosterone inhibitors with trimethoprim-sulfamethoxazole drug interaction(s) of risperidone with carbamazepine drug interaction(s) of salicylates with sulfonylureas drug interaction(s) of saquinavir with ritonavir drug interaction(s) of SGLT-2 inhititor (flozin) in combination with GLP1-agonist drug interaction(s) of simvastatin with amiodarone drug interaction(s) of simvastatin, verapamil & grapefruit drug interaction(s) of sofosbuvir with amiodarone drug interaction(s) of spironolactone with ACE inhibitors drug interaction(s) of spironolactone with beta blockers drug interaction(s) of spironolactone with potassium-sparing diuretics drug interaction(s) of spironolactone with trimethoprim drug interaction(s) of statins with antiviral protease inhibitors drug interaction(s) of statins with fibrates drug interaction(s) of statins with influenza virus vaccines drug interaction(s) of statins with macrolide drug interaction(s) of statins with SSRIs drug interaction(s) of statins with vitamin D drug interaction(s) of sulfonylureas with warfarin drug interaction(s) of tamoxifen with paroxetine drug interaction(s) of tamoxifen with SSRI drug interaction(s) of theophylline with fluoroquinolone drug interaction(s) of theophylline with fluvoxamine drug interaction(s) of theophylline with macrolide drug interaction(s) of tizanidine with ciprofloxacin drug interaction(s) of tizanidine with fluvoxamine drug interaction(s) of tofacitinib with shingles vaccine drug interaction(s) of tramadol with SSRIs drug interaction(s) of trazodone with SSRIs drug interaction(s) of tricyclic antidepressants with physostigmine drug interaction(s) of trimethoprim/sulfamethoxazole with warfarin drug interaction(s) of triptans with SNRIs drug interaction(s) of triptans with SSRIs drug interaction(s) of Vaccinium macrocarpon with warfarin drug interaction(s) of warfarin with antiplatelet agents drug interaction(s) of warfarin with chondroitin sulfate drug interaction(s) of warfarin with ginseng drug interaction(s) of warfarin with glucosamine drug interaction(s) of warfarin with Hyperocum perforatum drug interaction(s) of warfarin with NSAIDs drug interaction(s) of warfarin with Panax quinquefolius drug interaction(s) of xanthine oxidase inhibitors with azathioprine drug interaction(s) of Z-drugs with opiates drug interaction(s) SGLT2 inhibitors (flozins) with diuretics drug-nutrient interactions medication interactions with alcohol

General

iatrogenic disease

References

  1. Clinically Important Drug Interactions Encountered in Ambulatory and Community Pharmacy Practices Prescriber's Letter 11(6):31 2004 Detail-Document#: 200601 (subscription needed) http://www.prescribersletter.com
  2. Cytochrome P-450 Drug Interactions Prescriber's Letter 6(4): 1999 Detail-Document#: 150400 (subscription needed) http://www.prescribersletter.com
  3. Cytochrome P450 Drug-Interaction Table http://medicine.iupui.edu/flockhart/table.htm
  4. Prescriber's Letter 19(5): 2012 SPECIAL REPORT: Drug Interaction Overload: Problems and Solutions for Drug Interaction Alerts Detail-Document#: 280528 (subscription needed) http://www.prescribersletter.com
  5. Hines LE, Murphy JE. Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother. 2011 Dec;9(6):364-77 PMID: 22078863
  6. Mannheimer B, Eliasson E. Drug-drug interactions that reduce the formation of pharmacologically active metabolites: a poorly understood problem in clinical practice. J Intern Med. 2010 Dec;268(6):540-8. PMID: 21091806
  7. Seminerio MJ, Ratain MJ. Preventing adverse drug-drug interactions: a need for improved data and logistics. Mayo Clin Proc. 2013 Feb;88(2):126-8. PMID: 23374616
  8. Paauw DS Dangerous and Deadly Drug Combinations Medscape. June 30, 2016 http://www.medscape.com/features/slideshow/dangerous-drug-combinations
  9. Bakker T, Klopotowska JE, Dongelmans DA et al. The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: A cluster randomised stepped-wedge trial. Lancet 2024 Feb 3; 403:439. PMID: 38262430 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02465-0/abstract
  10. Medscape Drug Interaction Checker (accessed September 9, 2023) https://reference.medscape.com/drug-interactionchecker