drug/toxin-induced hepatitis

Etiology: 1) direct toxicity (dose-related) a) acetaminophen b) carbon tetrachloride c) mushrooms d) phosphorous 2) idiosyncratic (unpredictable) a) isoniazid b) disulfiram c) propylthiouracil 3) toxic-allergic a) halothane b) isoflurane c) tricrynafen 4) allergic hepatitis a) phenytoin b) amoxicillin-clavulanate c) sulfonamides 5) cholestatic a) chlorpromazine b) erythromycin estolate c) estradiol d) captopril e) sulfonamides 6) granulomatous a) diltiazem b) quinidine c) phenytoin d) procainamide 7) chronic hepatitis a) nitrofurantoin b) methyldopa c) isoniazid d) trazodone 8) alcohol-like hepatitis a) amiodarone b) perhexiline c) valproic acid 9) microvesicular steatosis a) tetracyclines b) aspirin c) zidovudine d) didanosine e) fialuridine 10) fibrosis or cirrhosis a) methotrexate b) vitamin A c) methyldopa 11) hepatic veno-occlusive disease a) cyclophosphamide b) other chemotherapeutic agents c) herbal teas 1] pennroyal 2] germander 3] chaprral leaf 4] comfry 5] jin bu huan 12) ischemic damage a) cocaine b) sustained-release niacin c) methylenedioxymethamphetamin 13) other a) ketoconazole b) penicillins c) dantrolene d) carbazepine

General

hepatitis adverse drug reaction (ADR)

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998