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dopamine D3 receptor (DRD3)
Function:
- one of the five types dopamine receptor
- activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
- interacts with CLIC6 (putative)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=2
Expression: brain
Pathology:
- genetic variation in DRD3 may be associated with susceptibility to hereditary essential tremor 1
General
dopamine receptor
Properties
SIZE: entity length = 400 aa
MW = 44 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-32}
MOTIF: N-glycosylation site {N12}
N-glycosylation site {N19}
transmembrane domain {33-55}
cytoplasmic loop {56-66}
transmembrane domain {67-92}
exoplasmic loop {93-104}
MOTIF: N-glycosylation site {N97}
cysteine residue {C103}
MODIFICATION: cysteine residue {C181}
transmembrane domain {105-126}
cytoplasmic loop {127-149}
transmembrane domain {150-172}
exoplasmic loop {173-185}
MOTIF: N-glycosylation site {N173}
cysteine residue {C181}
MODIFICATION: cysteine residue {C103}
transmembrane domain {186-209}
cytoplasmic loop {210-329}
transmembrane domain {330-351}
exoplasmic loop {352-366}
transmembrane domain {367-388}
cytoplasmic domain {389-400}
Database Correlations
OMIM correlations
MORBIDMAP 126451
UniProt P35462
Pfam PF00001
Entrez Gene 1814
Kegg hsa:1814
References
- UniProt :accession P35462
- SHMPD; Note: The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=DRD3
- Surmeier DJ, Reiner A, Levine MS, Ariano MA.
Are neostriatal dopamine receptors co-localized?
Trends Neurosci. 1993 Aug;16(8):299-305. Review.
PMID: 7691003