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Dr1-associated corepressor (Dr1-associated protein 1, negative cofactor 2 alpha, NC2 alpha, DRAP1)
Function:
1) association of DR1/DRAP1 heterodimer with TBP results in functional repression of both activated & basal transcription of class II genes (genes with TATA-box ???)
2) interaction precludes formation of a transcription-competent complex by inhibiting association of TFIIA &/or TFIIB with TBP
3) binds DNA
4) heterodimer with DR1
5) binds BTAF1
6) phosphorylation diminishes DNA binding, but has no effect on heterodimerization & TBP binding
Structure:
- contains 1 histone-fold domain
Alternative splicing: named isoforms=2
Expression: ubiquitous
General
DNA-binding protein
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 22 kD
entity length = 204 aa
COMPARTMENT: cell nucleus
MOTIF: lysine-rich region {3-6}
MOTIF: lysine residue (SEVERAL)
Histone-fold {13-76}
proline-rich region
SITE: 157-194
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 602289
UniProt Q14919
Pfam PF00808
References
UniProt :accession Q14919