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tumor necrosis factor receptor superfamily member 10A; death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD261 (TNFRSF10A, APO2, DR4, TRAILR1)
Function:
- receptor for the cytotoxic ligand TNFSF10/TRAIL
- the adapter molecule FADD recruits caspase-8 to the activated receptor; the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis
- TRAILR1 & TRAILR2 mediate apoptosis; TRAILR3 & TRAILR4 do not
- promotes the activation of NF-kappa-B
- can interact with TRADD & RIP
Structure:
- contains 1 death domain
- contains 3 TNFR-Cys repeats
Compartment: membrane
Expression:
- widely expressed
- high levels are found in spleen, peripheral blood leukocytes, small intestine & thymus
- also expressed in K562 erythroleukemia cells, MCF7 breast carcinoma cells & activated T-cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 468 aa
MW = 50 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
alanine-rich region {29-32}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S83}
TNFR-Cys {107-145}
MOTIF: cysteine residue {C132}
MODIFICATION: cysteine residue {C145}
cysteine residue {C145}
MODIFICATION: cysteine residue {C132}
TNFR-Cys {147-188}
MOTIF: cysteine residue {C148}
MODIFICATION: cysteine residue {C164}
N-glycosylation site {N156}
cysteine residue {C164}
MODIFICATION: cysteine residue {C148}
cysteine residue {C167}
MODIFICATION: cysteine residue {C180}
cysteine residue {C170}
MODIFICATION: cysteine residue {C188}
cysteine residue {C180}
MODIFICATION: cysteine residue {C167}
cysteine residue {C188}
MODIFICATION: cysteine residue {C170}
TNFR-Cys {189-229}
MOTIF: cysteine residue {C190}
MODIFICATION: cysteine residue {C204}
cysteine residue {C204}
MODIFICATION: cysteine residue {C190}
cysteine residue {C207}
MODIFICATION: cysteine residue {C221}
cysteine residue {C211}
MODIFICATION: cysteine residue {C229}
cysteine residue {C221}
MODIFICATION: cysteine residue {C207}
cysteine residue {C229}
MODIFICATION: cysteine residue {C211}
transmembrane domain {240-262}
death domain
NAME: death domain
SITE: 365-448
Ser phosphorylation site {S463}
Ser phosphorylation site {S466}
References
- OMIM :accession 603611
- UniProt :accession O00220
- Entrez Gene :accession 8797
Databases & Figures
OMIM 603611
UniProt O00220
PFAM correlations
Entrez Gene 8797
Kegg hsa:8797
TRAIL -> caspase 8 -> bid -> smac/diablo -> IAP ...