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tumor necrosis factor receptor superfamily member 25; WSL-1 protein; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; Death domain receptor 3; WSL protein; apoptosis-inducing receptor AIR; apo-3; lymphocyte-associated receptor of death; LARD (TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779)

Function: - receptor for TNFSF12/APO3L/TWEAK - interacts directly with the adapter TRADD - mediates activation of NF-kappa-B & induces apoptosis - may play a role in regulating lymphocyte homeostasis - interacts strongly via the death domains with TNFRSF1 & TRADD to activate at least 2 distinct signaling cascades, apoptosis & NF-kappa-B signaling. - interacts with BAG4 Structure: - homodimer - glycosylated (probable) - contains 1 death domain - contains 4 TNFR-Cys repeats Compartment: - isoforms 1,2,9,11: cell membrane - isoforms 3,4,5,6,7,8,10,12: secreted Alternative splicing: named isoforms=12 Expression: - abundantly expressed in thymocytes & lymphocytes - detected in lymphocyte-rich tissues incuding: thymus, colon, intestine, & spleen - also found in the prostate Note: - some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

General

glycoprotein tumor necrosis factor [TNF] receptor family

Properties

SIZE: entity length = 417 aa MW = 45 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-24} TNFR-Cys {34-71} MOTIF: cysteine residue {C35} MODIFICATION: cysteine residue {C47} cysteine residue {C47} MODIFICATION: cysteine residue {C35} cysteine residue {C48} MODIFICATION: cysteine residue {C61} cysteine residue {C51} MODIFICATION: cysteine residue {C70} cysteine residue {C61} MODIFICATION: cysteine residue {C48} N-glycosylation site {N67} cysteine residue {C70} MODIFICATION: cysteine residue {C51} TNFR-Cys {72-115} MOTIF: cysteine residue {C73} MODIFICATION: cysteine residue {C89} cysteine residue {C89} MODIFICATION: cysteine residue {C73} cysteine residue {C92} MODIFICATION: cysteine residue {C107} cysteine residue {C95} MODIFICATION: cysteine residue {C115} N-glycosylation site {N106} cysteine residue {C107} MODIFICATION: cysteine residue {C92} cysteine residue {C115} MODIFICATION: cysteine residue {C95} TNFR-Cys {116-163} MOTIF: cysteine residue {C117} MODIFICATION: cysteine residue {C130} cysteine residue {C130} MODIFICATION: cysteine residue {C117} cysteine residue {C138} MODIFICATION: cysteine residue {C155} cysteine residue {C141} MODIFICATION: cysteine residue {C162} cysteine residue {C155} MODIFICATION: cysteine residue {C138} cysteine residue {C162} MODIFICATION: cysteine residue {C141} TNFR-Cys {164-192} MOTIF: cysteine residue {C165} MODIFICATION: cysteine residue {C176} cysteine residue {C176} MODIFICATION: cysteine residue {C165} cysteine residue {C179} MODIFICATION: cysteine residue {C191} cysteine residue {C187} MODIFICATION: cysteine residue {C195} cysteine residue {C191} MODIFICATION: cysteine residue {C179} cysteine residue {C195} MODIFICATION: cysteine residue {C187} transmembrane domain {200-220} death domain NAME: death domain SITE: 332-413

Database Correlations

OMIM 603366 UniProt Q93038 PFAM correlations Entrez Gene 8718 Kegg hsa:8718

References

  1. UniProt :accession Q93038
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/tnfrsf25/