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dipeptidyl aminopeptidase-like protein 6; dipeptidylpeptidase VI; dipeptidylpeptidase 6; dipeptidyl peptidase IV-like protein; dipeptidyl aminopeptidase-related protein; DPPX (DPP6)
Function:
- may be involved in the physiological processes of brain function
- has no dipeptidyl aminopeptidase activity
- may modulate cell surface expression & the activity of K+ channel KCND2
- binds KCND2
Structure:
- homodimer
- belongs to the peptidase S9B family
Compartment: membrane
Alternative splicing: named isoforms=2; DPPX-L, DPPX-S
Expression: expressed predominantly in brain
Pathology:
- genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis
Laboratory:
- dipeptidyl aminopeptidase-like protein 6 IgG in CSF
- dipeptidyl aminopeptidase-like protein 6 IgG in serum/plasma
General
dipeptidase
Properties
SIZE: entity length = 865 aa
MW = 98 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {96-116}
N-glycosylation site {N173}
N-glycosylation site {N319}
N-glycosylation site {N404}
cysteine residue {C411}
MODIFICATION: cysteine residue {C418}
cysteine residue {C418}
MODIFICATION: cysteine residue {C411}
N-glycosylation site {N471}
cysteine residue {C527}
MODIFICATION: cysteine residue {C530}
cysteine residue {C530}
MODIFICATION: cysteine residue {C527}
N-glycosylation site {N535}
cysteine residue {C536}
MODIFICATION: cysteine residue {C554}
cysteine residue {C554}
MODIFICATION: cysteine residue {C536}
N-glycosylation site {N566}
cysteine residue {C735}
MODIFICATION: cysteine residue {C846}
N-glycosylation site {N813}
cysteine residue {C846}
MODIFICATION: cysteine residue {C735}
Database Correlations
OMIM 126141
MORBIDMAP 126141
UniProt P42658
PFAM correlations
Entrez Gene 1804
Kegg hsa:1804
References
UniProt :accession P42658