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dopaminergic receptor agonist

Adverse effects: 1) anorexia 2) nausea/vomiting 3) dizziness 4) dyskinesia a) usually choreiform movements b) effect is dose dependent c) generally occurs after prolonged therapy 5) psychosis a) visual hallucinations b) vivid nightmares c) paranoid delusions 6) impulse control disorders [4,5] 7) compulsive behavior - punding [3] - gambling, shopping, hypersexuality [3] 7) dementia 8) depression 9) sedation [3] 10) excessive daytime sleepiness & sleep attacks [2] Drug interactions: - dopaminergic receptor agonists can induce psychosis in patients taking antipsychotics

Interactions

drug adverse effects (more general classes)

Related

dopamine receptor

Specific

apomorphine (Apokyn, Uprima) bromocriptine (Parlodel, Cycloset) cabergoline (Dostinex) fenoldopam (Corlopam) lisuride (Cuvalit, Lysenyl, Eunal) pergolide (Permax, pergolidum) piribedil (Trivastal) pramipexole (Mirapex) ropinirole (Requip, Requip-XL) rotigotine (Neupro)

General

adrenergic receptor agonist

Properties

AGONIST-FOR: adrenergic receptor

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1051
  2. Prescriber's Letter 9(3):17 2002
  3. Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012 - Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  4. Moore TJ et al Reports of Pathological Gambling, Hypersexuality, and Compulsive Shopping Associated With Dopamine Receptor Agonist Drugs. JAMA Intern Med. Published online October 20, 2014. PMID: 25329919 http://archinte.jamanetwork.com/article.aspx?articleid=1916909 - Gagne JJ Finding Meaningful Patterns in Adverse Drug Event Reports. JAMA Intern Med. Published online October 20, 2014 PMID: 25329621 http://archinte.jamanetwork.com/article.aspx?articleid=1916906 - Weiss HD, Pontone GM Dopamine Receptor Agonist Drugs and Impulse Control Disorders. JAMA Intern Med. Published online October 20, 2014 PMID: 25329734 http://archinte.jamanetwork.com/article.aspx?articleid=1916907
  5. Corvol JC, Artaud F, Cormier-Dequaire F et al. Longitudinal analysis of impulse control disorders in Parkinson disease. Neurology. 2018 Jul 17;91(3):e189-e201. PMID: 29925549 http://n.neurology.org/content/91/3/e189