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dopamine D4 receptor; dopamine D2C receptor (DRD4)
Function:
- one of the five types of dopamine receptor
- activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
- interacts with CLIC6 (putative) & GPRASP1
- consensus sites for PKA & PKC phosphorylation
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Polymorphism:
- the number of repeats of 16 amino acids in the 3rd cytoplasmic loop is highly polymorphic & varies among different alleles
- the polymorphic repeat sequence has little influence on DRD4-binding profiles & might not be essential for G protein interaction
- 7R allele associated with longevity in mice & humans [3]
General
dopamine receptor
human longevity protein
Properties
SIZE: entity length = 467 aa
MW = 48 kD
COMPARTMENT: cytoplasm
MOTIF: exoplasmic domain {1-37}
MOTIF: N-glycosylation site {N3}
transmembrane domain {38-60}
cytoplasmic loop {61-70}
transmembrane domain {71-93}
exoplasmic loop {94-109}
MOTIF: cysteine residue {C108}
MODIFICATION: cysteine residue {C185}
transmembrane domain {110-131}
cytoplasmic loop {132-151}
transmembrane domain {152-175}
exoplasmic loop {176-191}
MOTIF: cysteine residue {C185}
MODIFICATION: cysteine residue {C108}
transmembrane domain {192-213}
cytoplasmic loop {214-394}
MOTIF: proline-rich region
SITE: 249-360
MOTIF: proline residue (SEVERAL)
transmembrane domain {395-417}
exoplasmic loop {418-426}
transmembrane domain {427-449}
cytoplasmic domain {450-467}
Database Correlations
OMIM 126452
UniProt P21917
Pfam PF00001
Entrez Gene 1815
Kegg hsa:1815
References
- UniProt :accession P21917
- Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P,
Niznik HB, Civelli O.
Cloning of the gene for a human dopamine D4 receptor with
high affinity for the antipsychotic clozapine.
Nature. 1991 Apr 18;350(6319):610-4.
PMID: 1840645
- Grady DL et al
DRD4 genotype predicts longevity in mouse and human.
J Neurosci 2013 Jan 2; 33:286
PMID: 23283341