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dopamine D1A receptor (DRD1)
Function:
- dopamine receptor
- activity of this receptor is mediated by G proteins which activate adenylyl cyclase
- interacts with DNAJC14 via its C-terminus
- linked to Gs in medium spiny neurons of striatum
Structure: belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane
- endoplasmic reticulum membrane
- transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 (putative)
- dopamine-D1 & D2 receptors colocalize in 60-80% of medium spiny neurons of striatum [3]
- D1 receptors are also present on spines of prefrontal pyramidal cells where it is thought that they modulate input of excitatory synapses during formation of short term or working memory [1]
Expression:
- detected in caudate, nucleus accumbens, olfactory tubercle
Interactions
molecular events
General
dopamine receptor
Properties
SIZE: entity length = 446 aa
MW = 49 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: exoplasmic domain {1-23}
MOTIF: N-glycosylation site {N5}
transmembrane domain {24-49}
cytoplasmic loop {50-60}
transmembrane domain {61-87}
exoplasmic loop {88-96}
MOTIF: cysteine residue {C96}
MODIFICATION: cysteine residue {C186}
transmembrane domain {97-119}
cytoplasmic loop {120-138}
transmembrane domain {139-163}
exoplasmic loop {164-192}
MOTIF: cysteine residue {C186}
MODIFICATION: cysteine residue {C96}
transmembrane domain {193-218}
cytoplasmic loop {219-272}
transmembrane domain {273-299}
exoplasmic loop {300-312}
transmembrane domain {313-337}
cytoplasmic domain {338-446}
MOTIF: cysteine residue {C347}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C351}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 126449
UniProt P21728
Pfam PF00001
KEGG correlations
References
- UniProt :accession P21728
- Goldman-Rakic PS.
Cellular basis of working memory.
Neuron. 1995 Mar;14(3):477-85. Review.
PMID: 7695894
- Surmeier DJ, Reiner A, Levine MS, Ariano MA.
Are neostriatal dopamine receptors co-localized?
Trends Neurosci. 1993 Aug;16(8):299-305. Review.
PMID: 7691003