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atropine/belladonna/hyoscyamine/phenobarbital/scopolamine (Donnatal)

Elixir. Belladonna alkaloids with phenobarbital. Indications: - adjunctive treatment for: a) peptic ulcer disease b) irritable bowel syndrome c) spastic colitis d) spastic bladder e) renal colic Contraindications: pregnancy-category C safety in lactation - Dosage: 1) adults: 1-2 tabs or 5-10 mL PO TID/QID 2) children: 0.1 mL/kg every 4 hours; max: 5mL/dose Tabs: (contain) - 16.2 mg phenobarbital - 0.02 mg atropine - 0.1 mg hyoscyamine - 6.5 mg scopolamine Elixir: contains equivalent of 1 tab/5 mL Pharmacokinetics: elimination: liver > kidney. Adverse effects: 1) common (> 10%) - constipation - decreased sweating - dry mouth, nose, throat or skin - irritation at site of injection 2) less common (1-10%) - decreased flow of breast milk - difficulty swallowing - increased sensitivity to light 3) uncommon (< 1%) - rash, confusion, increased intraocular pain, orthostatic hypotension, bloating, difficult urination, blurred vision, drowsiness, headache, loss of memory, nausea/vomiting, weakness, tiredness, ventricular fibrillation, tachycardia, palpitations, ataxia

General

antiulcer combination

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Component-of

Maalox/Mylanta/viscous lidocaine/Donnatal (GI cocktail, 'Green Goddess') Maalox/Mylanta/viscous lidocaine/Donnatal (GI cocktail, 'Green Goddess')

Components

atropine (Atropair, Atropine-Care) belladonna alkaloid hyoscyamine (Anaspaz, Levsin) phenobarbital; PB; PHB (Luminal, Barbita, Solfoton) scopolamine (Transderm Scop, Hyoscine)