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Donath-Landsteiner antibody test
Indications:
- paroxysmal cold hemoglobinuria
Clinical significance:
- test for paroxysmal cold hemoglobinuria
a) hemolysis activated by exposure of blood to cold
b) hemolysis takes place only after rewarming
- the Donath-Landsteiner antibody is due to an IgG autoantibody directed against P-antigen on RBC
- complement is activated & hemolysis results
Related
paroxysmal cold hemoglobinuria (PCH)
General
hemolysin cold in plasma; hemolysins & agglutinins, auto, screen
References
- Donath Landsteiner
Laboratory Test Directory ARUP: 13039