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docusate
Stool softeners.
Indications:
- constipation (hard stools)
Contraindications:
- in patients with serious illness docusate of no benefit
- CDC & FDA recommend against using any liquid docusate product [4]
Epidemiology:
- multi-state outbreak of Burkholderia cepacia infection from liquid docusate [2]
Specific
calcium docusate (Surfak)
sodium docusate (Colace, DOSS, DSS)
General
laxative
Properties
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Centers for Disease Control & Prevention (CDC).
Healthcare-associated Infections. July 8, 2016
Multistate Outbreak of Burkholderia cepacia Infections
https://www.cdc.gov/hai/outbreaks/b-cepacia/index.html
- Tarumi Y, Wilson MP, Szafran O, Spooner GR.
Randomized, double-blind, placebo-controlled trial of oral
docusate in the management of constipation in hospice patients.
J Pain Symptom Manage. 2013 Jan;45(1):2-13.
PMID: 22889861
- Brooks M
FDA Warns Against Use of Any Liquid Product From PharmaTech
Medscape - Aug 09, 2017.
http://www.medscape.com/viewarticle/883981
- Medical Knowledge Self Assessment Program (MKSAP) 19.
American College of Physicians, Philadelphia 2021
Component-of
benzocaine/docusate
casanthranol/docusate (Peri-Colace)
docusate/ferrous fumarate
docusate/phenolphthalein