dedicator of cytokinesis protein 3; modifier of cell adhesion; presenilin-binding protein; PBP (DOCK3, KIAA0299, MOCA)

Function: 1) guanine nucleotide exchange factor (putative) 2) interacts with presenilins 3) stimulates MAPT (tau) phosphorylation 4) regulation of actin cytoskeleton or cell adhesion receptors (putative) 5) interacts with presenilins PSEN1, PSEN2, CRK Structure: - the DHR-2 domain may mediate some GEF activity - belongs to the DOCK family - contains 1 DHR-1 domain - contains 1 DHR-2 domain - contains 1 SH3 domain Compartment: cytoplasm Expression: - in normal brains, localized in the neuropil, & occasionally in pyramidal cells Pathology: - in Alzheimer disease brains, associated with neurofibrillary tangles - chromosomal inversion inv(3)(p14:q21) involving DOCK3 & SLC9A9 associated with ADHD

General

dedicator of cytokinesis protein (DOCK) phosphoprotein

Properties

SIZE: entity length = 2030 aa MW = 233 kD COMPARTMENT: cytoplasm MOTIF: src homology 3 [SH3] domain SITE: 6-67 DHR-1 {421-599} DHR-2 {1228-1635} serine-rich region {1731-1768} MOTIF: serine residue (SEVERAL) SH3-binding site NAME: SH3-binding site SITE: 1970-1976 Ser phosphorylation site {S2013}

Database Correlations

OMIM 603123 UniProt Q8IZD9 PFAM correlations Entrez Gene 1795 Kegg hsa:1795

References

UniProt :accession Q8IZD9