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deoxynucleotidyltransferase terminal-interacting protein 2 (terminal deoxynucleotidyltransferase-interacting factor 2, TdT-interacting factor 2, estrogen receptor-binding protein, LPTS-interacting protein 2, LPTS-RP2, DNTTIP2, ERBP, TDIF2)
Function:
- regulates the transcriptional activity of DNTT & ESR1
- may function as a chromatin remodeling protein
- forms a ternary complex with DNTT & core histone interaction with PCNA releases DNTT & H2A/H2B histones from this ternary complex
- interacts with ESR1, ESR2, PPARG & RXRA
Compartment: nucleus
Expression: widely expressed with higher levels in testis
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 756 aa
MW = 84 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S117}
Ser phosphorylation site {S121}
Ser phosphorylation site {S184}
Ser phosphorylation site {S189}
Ser phosphorylation site {S190}
Ser phosphorylation site {S191}
Thr phosphorylation site {T232}
coiled coil {505-542}
MOTIF: Ser phosphorylation site {S528}
Ser phosphorylation site {S532}
Ser phosphorylation site {S533}
Ser phosphorylation site {S543}
TdBR region; mediates interaction with DNTT {548-605}
Database Correlations
UniProt Q5QJE6
Pfam PF08698
Kegg hsa:3083
References
UniProt :accession Q5QJE6