dynamin-binding protein; scaffold protein tuba (DNMBP, KIAA1010)

Function: - scaffold protein - links dynamin with actin-regulating proteins - may play a role in membrane trafficking between the cell surface & the Golgi (putative) - binds DNM1 via its N-terminal SH3 domains - the C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 & actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 & NAP1L1 (putative) - interacts with FASLG Structure: - contains 1 BAR domain - contains 1 DH (DBL-homology) domain - contains 6 SH3 domains Compartment: - cytoplasm, cytoskeleton (putative) - Golgi; Golgi stack (putative) - cell junction, synapse (putative) - localized to synapses & Golgi stacks (putative) Alternative splicing: named isoforms=2 Expression: - expressed in heart, brain, lung, liver, skeletal muscle, kidney & pancreas

Properties

SIZE: entity length = 1577 aa MW = 177 kD COMPARTMENT: cytoplasm golgi MOTIF: src homology 3 [SH3] domain SITE: 2-61 src homology 3 [SH3] domain SITE: 66-126 src homology 3 [SH3] domain SITE: 145-204 src homology 3 [SH3] domain SITE: 243-302 proline-rich region SITE: 610-649 MOTIF: proline residue (SEVERAL) coiled coil {693-757} membrane region Dbl homology domain {784-967} BAR {1008-1217} MOTIF: coiled coil {1136-1173} src homology 3 [SH3] domain SITE: 1285-1348 serine-rich region {1351-1449} MOTIF: serine residue (SEVERAL) src homology 3 [SH3] domain SITE: 1513-1576

Database Correlations

OMIM 611282 UniProt Q6XZF7 PFAM correlations Entrez Gene 23268 Kegg hsa:23268

References

UniProt :accession Q6XZF7