dynein light chain 2A (dynein light chain roadblock-type 1, dynein-associated protein Km23, bithoraxoid-like protein, BLP, DNCL2A, DNLC2A, BITH)

Function: - dynein light chain - may be involved in assembly & motor function of dynein Structure: belongs to the GAMAD family Compartment: cytoplasm Alternative splicing: - named isoforms=2 - additional isoforms seem to exist & may result from the retention of an intron in the cDNA Expression: - expression in heart, liver, brain & pancreas > placenta, skeletal muscle & kidney > lung, prostate, testis, small intestine & colon Pathology: - isoform 1 expression is up-regulated in 64% of hepatocellular carcinoma

General

dynein light chain protease inhibitor

Properties

COMPARTMENT: cytoplasm INHIBITS: protease SIZE: MW = 11 kD entity length = 96 aa

Database Correlations

OMIM 607167 UniProt Q9NP97 Pfam PF03259 Kegg hsa:8365

References

UniProt :accession Q9NP97