DnaJ homolog subfamily C member 7; tetratricopeptide repeat protein 2; TPR repeat protein 2 (DNAJC7, TPR2, TTC2)

Function: - acts as co-chaperone regulating the molecular chaperones HSP70 & HSP90 in folding of steroid receptors, such as the glucocorticoid receptor & the progesterone receptor - recycling chaperone by facilitating return of chaperone substrates to early stages of chaperoning if further folding is required (putative) - in vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes - recruits CXADR to the cytoplasm - associates with complexes containing chaperones HSP70 & HSP90 - interacts with the GAP domain of NF1 - interacts with HSP90AA1 - interacts with HSPA1A/B; the interaction is enhanced by ATP - interacts with HSP90AB1 - interacts with PGR - interacts with RAD9A; the interaction is interrupted by UV & heat shock treatments - interacts with HUS1 & RAD1 - interacts with CXADR - probably part of a complex containing CXADR, HSP90AA1 & DNAJC7 - interacts with HSPA8 Structure: - contains 1 J domain - contains 9 TPR repeats Compartment: - cytoplasm, nucleus, cytoskeleton - colocalizes with CXADR to microtubules

General

DNAJ homolog subfamily C phosphoprotein tetratricopeptide repeat protein

Properties

SIZE: entity length = 494 aa MW = 56 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl tetratricopeptide repeat {28-61} MOTIF: Tyr phosphorylation site {Y50} tetratricopeptide repeat {62-95} tetratricopeptide repeat {96-129} tetratricopeptide repeat {142-175} tetratricopeptide repeat {177-209} tetratricopeptide repeat {210-243} tetratricopeptide repeat {256-289} tetratricopeptide repeat {294-327} tetratricopeptide repeat {328-361} J domain {381-451}

Database Correlations

OMIM 601964 UniProt Q99615 PFAM correlations Entrez Gene 7266

References

UniProt :accession Q99615