dynein heavy chain 11; ciliary dynein heavy chain 11; axonemal dynein heavy chain 11 (DNAH11)

Function: - dynein heavy chain - force generating protein of respiratory cilia Structure: - belongs to the dynein heavy chain family (see dynein heavy chain) Pathology: - defects in DNAH11 are a cause of: a) situs inversus viscerum b) primary ciliary dyskinesia

Related

cytoplasmic dynein 2 heavy chain 1; cytoplasmic dynein 2 heavy chain; dynein cytoplasmic heavy chain 2; dynein heavy chain isotype 1B; dynein heavy chain 11; hDHC11 (DYNC2H1, DHC1B, DHC2, DNCH2, DYH1B, KIAA1997) dynein

Properties

SIZE: entity length = 4523 aa MW = 521 kD MOTIF: Stem {1-1861} MOTIF: coiled coil {1274-1327} AAA 1 {1862-2083} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 1900-1907 AAA 2 {2143-2373} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 2181-2188 AAA 3 {2479-2726} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 2517-2524 AAA 4 {2824-3073} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 2862-2869 Stalk {3079-3410} MOTIF: coiled coil {3079-3143} coiled coil {3319-3410} AAA 5 {3466-3693} coiled coil {3675-3710} AAA 6 {3903-4129}

Database Correlations

OMIM correlations MORBIDMAP 603339 UniProt Q96DT5 PFAM correlations Kegg hsa:8701

References

UniProt :accession Q96DT5