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DNA polymerase epsilon

Function: - role in DNA repair & in chromosomal DNA replication - the yeast DNA polymerase epsilon is a G1/S checkpoint DNA repair polymerase - elongation of primed DNA templates by DNA polymerase epsilon requires the action of the accessory proteins PCNA & replication factor C Structure: - consists of four subunits: POLE1, POLE2, POLE3 & POLE4 - yeast DNA polymerase epsilon contains an N-terminal polymerase domain & a C-terminal checkpoint domain that senses DNA replication [2]

Related

proliferating cell nuclear antigen (PCNA)

General

DNA polymerase exodeoxyribonuclease multisubunit protein

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Properties

COMPARTMENT: cell nucleus SUBUNITS: DNA polymerase epsilon catalytic subunit MOTIF: Ser phosphorylation site {S1940} Zn finger C4-type SITE: 2158-2190 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 2221-2238 EFFECTOR-BOUND: Zn+2 DNA polymerase epsilon 55 kD subunit

References

  1. Linn S How many pols does it take to replicate nuclear DNA? Cell 66:185 1991 PMID: 1855251
  2. Navas et al Cell 80:29 1995

Components

DNA polymerase epsilon 55 kD subunit (subunit B or subunit 2, POLE2) DNA polymerase epsilon catalytic subunit (subunit A, subunit 1, POLE, POLE1)