DNA polymerase delta

Function: - associated with proliferating cell nuclear antigen (PCNA) & replication factor C for efficient activity - is this the polymerase that replicates viral DNA? Structure: - heterotetramer

General

DNA polymerase exodeoxyribonuclease multisubunit protein

Properties

COMPARTMENT: cell nucleus SUBUNITS: DNA polymerase delta catalytic MOTIF: nuclear translocation signal {4-19} Zn finger C4-type SITE: 1012-1029 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 1058-1076 EFFECTOR-BOUND: Zn+2 DNA polymerase delta regulatory DNA polymerase delta subunit p66 MOTIF: Ser phosphorylation site {S307} Ser phosphorylation site {S407} Ser phosphorylation site {S409} Thr phosphorylation site {T411} Ser phosphorylation site {S413} DNA polymerase delta subunit p12

References

Linn S How many pols does it take to replicate nuclear DNA? Cell 66:185 1991 PMID: 1855251

Components

DNA polymerase delta regulatory p48 (DNA polymerase delta subunit 2, POLD2) DNA polymerase delta subunit p12 (DNA polymerase delta subunit 4, POLD4) DNA polymerase delta subunit p66 (DNA polymerase delta subunit 3, POLD3) DNA polymerase delta-1 catalytic subunit (POLD1)