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Ca+2 & integrin-binding protein 1; CIB; Ca+2- & integrin-binding protein; CIBP; calmyrin; DNA-PKcs-interacting protein; kinase-interacting protein; KIP; SNK-interacting protein 2-28; SIP2-28 (CIB1, CIB, KIP, PRKDCIP)
Function:
- may convert the inactive conformation of integrin alpha-2b/beta-3 to an active form through binding tothe integrin cytoplasmic domain
- induces cell migration & spreading mediated through integrin (possibly via focal adhesion complexes)
- negative regulator of stress activated MAP kinase (MAPK) signaling pathways
- may play a role in regulation of apoptosis
- interacts with & up-regulates PTK2 activity
- down regulates inositol 1,4,5-trisphosphate receptor- dependent Ca+2 signaling
- interacts with the heterodimeric integrin alpha-2b/beta-3
- interacts with the protein kinases PLK2/SNK & with the region immediately upstream of the kinase domain of DNA-PK
- interacts with PSEN2
- interacts with MYO1C (putative)
- interacts (via C-terminus) with F8
- interacts with NBR1 (via C-terminus)
- interacts with FEZ1 (via C-terminus)
- interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, & may target CIB1 for ubiquitin- mediated degradation
- interacts with IFI6
- interacts with BCL2
- interacts with TAS1R2 (via C-terminus); this interaction is independent of myristoylation
- interacts with ITPR3 (Ca+2 dependent)
- interacts with PTK2
- interacts with MAP3K5, inhibiting MAP3K5 activation by phosphorylation, & its subsequent interaction with TRAF2
Structure:
- monomer
- contains 2 EF-hand domains
Compartment:
- membrane; lipid-anchor
- cytoplasm, nucleus
- cell projection, filopodium, apical cell membrane
- localizes to the perinuclear region in the presence of NBR1
- colocalizes with TAS1R2 in apical regions of taste receptor cells
Expression: ubiquitous
General
Ca+2 binding protein
myristoylated protein
Properties
SIZE: entity length = 191 aa
MW = 22 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
EF hand
SITE: 103-138
MOTIF: Ca+2-binding site
SITE: 116-127
EF hand
SITE: 148-183
MOTIF: Ca+2-binding site
SITE: 161-172
Database Correlations
OMIM 602293
UniProt Q99828
Entrez Gene 10519
Kegg hsa:10519
References
UniProt :accession Q99828