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DNA mismatch repair; post-replication repair; DNA loop repair

Also referred to as DNA loop repair & post-replication repair. Biochemistry: - DNA mismatch repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination & as a result of DNA damage - mismatch repair deficiency can be observed in phenotypically normal cells Pathology: - genetic defects in mismatch repair genes play an important role in common cancer-susceptibility syndromes & sporadic cancers - hereditary nonpolyposis colon cancer is a common inherited cancer susceptibility syndrome associated with a defect in mismatch repair - 10-20% of sporadic tumors show microsatellite instability, a marker of mismatch repair deficiency. Comparative biology: - some of these systems are conserved in prokaryotes & eukaryotes

Related

DNA mismatch repair protein Mlh1; mutL protein homolog 1 (MLH1, COCA2) DNA mismatch repair protein Msh2; hMSH2; mutS protein homolog 2 (MSH2) DNA mismatch repair protein Msh3; MutS holomolog 3; divergent upstream protein; DUP; mismatch repair protein 1; MRP1 (MSH3, DUC1, DUG) DNA mismatch repair protein Msh6; hMSH6; mutS-alpha 160 kD subunit; p160; G/T mismatch-binding protein; GTMBP; GTBP (MSH6 GTBP) familial nonpolyposis colon cancer; hereditary nonpolyposis colorectal cancer (HNPCC); Lynch syndrome; cancer family syndrome Mismatch repair endonuclease PMS2; PMS1 protein homolog 2; DNA mismatch repair protein PMS2; postmeiotic segregation increased-2 (PMS2, PMSL2) PMS1 protein homolog 1; postmeiotic segregation increased-1; DNA mismatch repair protein PMS1 (PMS1, PMSL1)

Useful

mismatch repair (GO:0006298)

General

DNA repair

Figures/Diagrams

Figures/diagrams/slides/tables related to DNA mismatch repair

References

  1. Kolodner RD. Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem Sci. 1995 Oct;20(10):397-401. Review. PMID: 8533151
  2. Karran P. Appropriate partners make good matches. Science. 1995 Jun 30;268(5219):1857-8. Review. PMID: 7604258
  3. Umar A, Boyer JC, Kunkel TA. DNA loop repair by human cell extracts. Science. 1994 Nov 4;266(5186):814-6. PMID: 7973637
  4. Parsons R, Li GM, Longley M, Modrich P, Liu B, Berk T, Hamilton SR, Kinzler KW, Vogelstein B. Mismatch repair deficiency in phenotypically normal human cells. Science. 1995 May 5;268(5211):738-40. PMID: 7632227